' 
SCIENTIFIC SCORE
Moderately Effective
Based on 11 Researches
8.3
USERS' SCORE
Good
Based on 1 Review
8.5
Supplement Facts
Serving Size: 1 Capsule
Amount Per Serving
%DV
Milk Thistle Seed 30:1 Extract(Silybum marianum) (Fruit/Seed) (80% [120 mg] Total Flavonoids)
150 mg
†
Top Medical Research Studies
8
SM reduces cardiac triglyceride levels
Triglyceride-induced cardiac lipotoxicity is mitigated by Silybum marianum.
Relevant in cardiovascular research
We examined the effects of Silybum marianum (SM) on heart health through a study on pigs with myocardial infarction. Our findings revealed that administering SM for ten days significantly lowered plasma triglycerides and reduced triglyceride absorption.
Notably, this outcome correlated with reduced cardiac lipotoxicity three weeks after the heart incident and better cardiac structure. Importantly, we observed no adverse effects from SM. Overall, while SM shows promise in improving certain heart conditions, further research could clarify its broader application.
Notably, this outcome correlated with reduced cardiac lipotoxicity three weeks after the heart incident and better cardiac structure. Importantly, we observed no adverse effects from SM. Overall, while SM shows promise in improving certain heart conditions, further research could clarify its broader application.
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9
Silybum marianum aids heart recovery
Silybum marianum provides cardioprotection and limits adverse remodeling post-myocardial infarction by mitigating oxidative stress and reactive fibrosis.
Moderate relevance of findings
We explored the impact of the herb, Silybum marianum, on heart health following a heart attack in pigs. The study involved several phases to assess its protective properties during and after a myocardial infarction.
Our findings showed that those treated with Silybum had reduced heart damage and improved cardiac healing compared to controls. This benefit seems linked to its antioxidant and antifibrotic effects, which help the heart recover better following an injury.
However, no significant effects were observed in hearts that did not experience a heart attack.
Our findings showed that those treated with Silybum had reduced heart damage and improved cardiac healing compared to controls. This benefit seems linked to its antioxidant and antifibrotic effects, which help the heart recover better following an injury.
However, no significant effects were observed in hearts that did not experience a heart attack.
Read More
9
Silybum marianum's protective effects
Silymarin component 2,3-dehydrosilybin attenuates cardiomyocyte damage following hypoxia/reoxygenation by limiting oxidative stress.
Significant cardioprotective potential
We explored how 2,3-dehydrosilybin (DHS), a compound from Silybum marianum, impacts heart cells following periods of low oxygen and subsequent reoxygenation. In our study, neonatal rat heart cells were exposed to stress conditions while some were treated with DHS.
The results showed that DHS effectively reduced harmful oxidative stress in these cells. We found that it lessened cell damage and improved cell survival, suggesting that DHS might mimic protective strategies typically used in heart injury. However, further research is needed to fully understand its potential benefits in real-life scenarios.
The results showed that DHS effectively reduced harmful oxidative stress in these cells. We found that it lessened cell damage and improved cell survival, suggesting that DHS might mimic protective strategies typically used in heart injury. However, further research is needed to fully understand its potential benefits in real-life scenarios.
Read More
Most Useful Reviews
8.8
Liver detoxification
I recommend Milk Thistle as it effectively treats food poisoning, chronic intoxication, and is beneficial for acquired immunodeficiencies, diabetes, obesity, and to mitigate the risk of cardiovascular disease. It aids in cleansing the liver, blood, and body of toxins, particularly after chemotherapy or radiation therapy.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 11 Researches
8.3
- All Researches
9
Silybum marianum shows potential benefits
Preventive and Therapeutic Effects of Seed Extract Rich in Silydianin and Silychristin in a Rat Model of Metabolic Syndrome.
Highly relevant cardiovascular study
We explored the possible effects of silybum marianum seed extract on metabolic syndrome, a condition that can lead to heart disease. Using a rat model fed a high-fat and high-fructose diet, we observed that the extract significantly lowered triglyceride and glucose levels, helped control weight gain, and reduced blood pressure.
Overall, our findings suggest that silybum marianum has promising preventive and therapeutic effects on metabolic syndrome. However, further studies and clinical trials are necessary to confirm these benefits in humans.
Overall, our findings suggest that silybum marianum has promising preventive and therapeutic effects on metabolic syndrome. However, further studies and clinical trials are necessary to confirm these benefits in humans.
Read More
9
Silybum marianum aids heart recovery
Silybum marianum provides cardioprotection and limits adverse remodeling post-myocardial infarction by mitigating oxidative stress and reactive fibrosis.
Moderate relevance of findings
We explored the impact of the herb, Silybum marianum, on heart health following a heart attack in pigs. The study involved several phases to assess its protective properties during and after a myocardial infarction.
Our findings showed that those treated with Silybum had reduced heart damage and improved cardiac healing compared to controls. This benefit seems linked to its antioxidant and antifibrotic effects, which help the heart recover better following an injury.
However, no significant effects were observed in hearts that did not experience a heart attack.
Our findings showed that those treated with Silybum had reduced heart damage and improved cardiac healing compared to controls. This benefit seems linked to its antioxidant and antifibrotic effects, which help the heart recover better following an injury.
However, no significant effects were observed in hearts that did not experience a heart attack.
Read More
9
Effective treatment for cholesterol
Effects of a Combination of Berberis aristata, Silybum marianum and Monacolin on Lipid Profile in Subjects at Low Cardiovascular Risk; A Double-Blind, Randomized, Placebo-Controlled Trial.
High relevance, significant findings
We evaluated how a combination of Berberis aristata, Silybum marianum, and Monacolin affects cardiovascular health. In a double-blind, placebo-controlled trial with 143 Caucasian patients at low cardiovascular risk, we observed significant improvements in cholesterol and inflammatory markers.
The group using Berberol K saw notable reductions in total cholesterol, triglycerides, and LDL, alongside decreases in high sensitivity C-reactive protein and interleukin-6. Our findings suggest that this combination may be not only effective but also safe for improving cardiovascular health.
The group using Berberol K saw notable reductions in total cholesterol, triglycerides, and LDL, alongside decreases in high sensitivity C-reactive protein and interleukin-6. Our findings suggest that this combination may be not only effective but also safe for improving cardiovascular health.
Read More
9
Silybum marianum's protective effects
Silymarin component 2,3-dehydrosilybin attenuates cardiomyocyte damage following hypoxia/reoxygenation by limiting oxidative stress.
Significant cardioprotective potential
We explored how 2,3-dehydrosilybin (DHS), a compound from Silybum marianum, impacts heart cells following periods of low oxygen and subsequent reoxygenation. In our study, neonatal rat heart cells were exposed to stress conditions while some were treated with DHS.
The results showed that DHS effectively reduced harmful oxidative stress in these cells. We found that it lessened cell damage and improved cell survival, suggesting that DHS might mimic protective strategies typically used in heart injury. However, further research is needed to fully understand its potential benefits in real-life scenarios.
The results showed that DHS effectively reduced harmful oxidative stress in these cells. We found that it lessened cell damage and improved cell survival, suggesting that DHS might mimic protective strategies typically used in heart injury. However, further research is needed to fully understand its potential benefits in real-life scenarios.
Read More
8
Animal study shows silymarin promise
Cardioprotective and Hepatoprotective Potential of Silymarin in Paracetamol-Induced Oxidative Stress.
Study underscores potential therapeutic benefits
We explored the effects of silymarin on heart and liver protection against oxidative stress caused by paracetamol. In a study involving 28 male mice, groups received either control, paracetamol, silymarin, or a combination of silymarin and paracetamol over seven days.
Our findings indicated that silymarin significantly reduced markers of liver damage and oxidative stress. Additionally, a similar protective trend was observed in the heart tissue. While the results are promising, they primarily stem from animal models and further human studies are needed to confirm efficacy.
Our findings indicated that silymarin significantly reduced markers of liver damage and oxidative stress. Additionally, a similar protective trend was observed in the heart tissue. While the results are promising, they primarily stem from animal models and further human studies are needed to confirm efficacy.
Read More
User Reviews
USERS' SCORE
Good
Based on 1 Review
8.5
- All Reviews
- Positive Reviews
- Negative Reviews
8.8
Liver detoxification
I recommend Milk Thistle as it effectively treats food poisoning, chronic intoxication, and is beneficial for acquired immunodeficiencies, diabetes, obesity, and to mitigate the risk of cardiovascular disease. It aids in cleansing the liver, blood, and body of toxins, particularly after chemotherapy or radiation therapy.
Read More
